Blar i Brage NMBU på forfatter "Verhaegen, Steven"
-
A human relevant mixture of persistent organic pollutants (POPs) and perfluorooctane sulfonic acid (PFOS) differentially affect glutamate induced excitotoxic responses in chicken cerebellum granule neurons (CGNs) in vitro
Yadav, Ajay; Verhaegen, Steven; Verbruggen, Evelien; Kerhoas, Marie; Huiberts, Eva Henriëtte Willemijn; Hadera, Mussie Ghezu; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Ropstad, Erik; Paulsen, Ragnhild Elisabeth (Peer reviewed; Journal article, 2021)Primary cultures of cerebellar granule neurons (CGNs) derived from chicken embryos were used to explore the effects on developmental neurotoxicity by a complex defined mixture of persistent organic pollutants (POPs). Its ... -
Effects of Defined Mixtures of Persistent Organic Pollutants (POPs) on Pre-lethal Cytotoxicity in the Human A-498 Kidney Cell Line In Vitro
Amber, Mazia; Xie, Yuling; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Ropstad, Erik; Verhaegen, Steven; Connolly, Lisa (Peer reviewed; Journal article, 2021)A total mixture of 29 persistent organic pollutants (POPs) modelled from Scandinavian blood concentrations was used to expose human A-498 kidney cells for 24 h over a concentration range spanning below to above blood level ... -
Effects of persistent organic pollutants (POPs) on the steroidogenesis of primary neonatal porcine Leydig cells
Bjørklund, Cesilie Granum (PhD thesis;2019:7, Doctoral thesis, 2019)After World War II the production of manmade chemicals has increased immensely. They are made to give desired practical properties and functions. Some are added to consumer products to provide conductivity, increase flame ... -
Exposure to a human relevant mixture of persistent organic pollutants or to perfluorooctane sulfonic acid alone dysregulates the developing cerebellum of chicken embryo
Yadav, Ajay; Verhaegen, Steven; Filis, Panagiotis; Domanska, Diana; Lyle, Robert; Sundaram, Arvind; Leithaug, Magnus; Østby, Gunn Charlotte; Aleksandersen, Mona; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Fowler, Paul A.; Paulsen, Ragnhild Elisabeth Heimtun; Ropstad, Erik (Peer reviewed; Journal article, 2022)Prenatal exposure to persistent organic pollutants (POPs) is associated with neurodevelopmental disorders. In the present study, we explored whether a human-relevant POP mixture affects the development of chicken embryo ... -
Human blood-based exposure levels of persistent organic pollutant (POP)mixtures antagonise androgen receptor transactivation and translocation
McComb, J.; Mills, I.G.; Muller, M.; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Ropstad, Erik; Verhaegen, Steven; Connolly, S. (Journal article; Peer reviewed, 2019)Introduction Human exposure to persistent organic pollutants (POPs) has been linked to genitourinary health-related conditions such as decreased sperm quality, hypospadias, and prostate cancer (PCa). Conventional risk ... -
A human relevant mixture of persistent organic pollutants (POPs) and perfluorooctane sulfonic acid (PFOS) enhance nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells
Yadav, Ajay; Amber, Mazia; Zosen, Denis; Labba, Nils Anders; Huiberts, Eva Henriette Willemijn; Samulin-Erdem, Johanna Maria; Haugen, Fred; Berntsen, Hanne Friis; Zienolddiny, Shanbeh; Paulsen, Ragnhild Elisabeth; Ropstad, Erik; Connolly, Lisa; Verhaegen, Steven (Peer reviewed; Journal article, 2020)Disruption of neurite outgrowth is a marker for neurotoxicity. Persistent organic pollutants (POPs) are potential developmental neurotoxicants. We investigated their effect on neurite outgrowth in PC12 rat pheochromocytoma ... -
Human‑Based Exposure Levels of Perfluoroalkyl Acids May Induce Harmful Effects to Health by Disrupting Major Components of Androgen Receptor Signalling In Vitro
McComb, J.; Mills, I.G.; Berntsen, Hanne Friis; Ropstad, Erik; Verhaegen, Steven; Connolly, L. (Peer reviewed; Journal article, 2019) -
Lipogenic Potency of Individual Perfuorinated Alkyl Acids (PFAAs) and Persistent Organic Pollutant (POP) Mixtures at Human Blood‑Based Exposure Levels on Adipogenesis in 3T3‑L1 Cells
Xie, Y.; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Ropstad, Erik; Verhaegen, Steven; Connolly, L. (Peer reviewed; Journal article, 2021)In recent decades, the incidence of metabolic disorders has increased internationally. This increase has been linked to exposure to persistent organic pollutants (POPs), but little is known about the metabolic efects of ... -
Microcystins and Microcystis aeruginosa PCC7806 extracts modulate steroidogenesis differentially in the human H295R adrenal model
Mallia, Vittoria; Verhaegen, Steven; Styrishave, Bjarne; Eriksen, Gunnar Sundstøl; Johannesen, Malene Louise; Ropstad, Erik; Uhlig, Silvio (Peer reviewed; Journal article, 2020)The aim of this study was to investigate the potential interference of cyanobacterial metabolites, in particular microcystins (MCs), with steroid hormone biosynthesis. Steroid hormones control many fundamental processes ... -
Neurodevelopmental toxicity of a human relevant mixture of persistent organic pollutants (POPs) and perfluorooctane sulfonic acid (PFOS)
Yadav, Ajay (PhD Thesis;2021:63, Doctoral thesis, 2021)Persistent organic pollutants (POPs) are ubiquitous in the environment. Humans are continuously exposed to chemical mixtures through food and the environment. Exposure to POPs have been associated with several adverse ... -
Perfluoroalkyl acids potentiate glutamate excitotoxicity in rat cerebellar granule neurons
Berntsen, Hanne Friis; Moldes-Anaya, Angel; Bjørklund, Cesilie Granum; Ragazzi, Lorenzo; Haug, Trude M; Strandabø, Rønnaug; Verhaegen, Steven; Paulsen, Ragnhild Elisabeth; Ropstad, Erik; Tasker, Andrew (Peer reviewed; Journal article, 2020)Perfluoroalkyl acids (PFAAs) are persistent man-made chemicals, ubiquitous in nature and present in human samples. Although restrictions are being introduced, they are still used in industrial processes as well as in ... -
Perinatal exposure to a human relevant mixture of persistent organic pollutants: Effects on mammary gland development, ovarian folliculogenesis and liver in CD-1 mice
Johanson, Silje Modahl; Ropstad, Erik; Østby, Gunn Charlotte; Aleksandersen, Mona; Zamaratskaia, Galia; Boge, Gudrun Seeberg; Halsne, Ruth; Trangerud, Cathrine; Lyche, Jan Ludvig; Berntsen, Hanne Friis; Zimmer, Karin Elisabeth; Verhaegen, Steven (Peer reviewed; Journal article, 2021)The ability of persistent organic pollutants (POPs) with endocrine disrupting properties to interfere with the developing reproductive system is of increasing concern. POPs are transferred from dams to offspring and the ... -
Peripherally administered persistent organic pollutants distribute to the brain of developing chicken embryo in concentrations relevant for human exposure
Yadav, Ajay; Verhaegen, Steven; Hadera, Mussie Ghezu; Berntsen, Hanne Friis; Berg, Vidar; Lyche, Jan Ludvig; Sabaredzovic, Azemira; Haug, Line Småstuen; Myhre, Oddvar; Zimmer, Karin Elisabeth; Paulsen, Ragnhild Elisabeth; Ropstad, Erik; Boix, Fernando (Peer reviewed; Journal article, 2021) -
Persistent organic pollutants and effects on developmental and functional processes in mice
Johanson, Silje Modahl (PhD Thesis;2020:45, Doctoral thesis, 2020)Initial exposure to persistent organic pollutants (POPs) occurs by placental and lactational transfer during fetal and neonatal life and continues during the adult stage through ingestion, inhalation and dermal absorption. ...